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Amorphous solid dispersions API ASD Bicarbonate buffer bitter API CELLETS® coating coating weight gain dissolution drug load Dysphagia film thickness fluid bed fluidized bed friability geriatrics hot-melt Hydrocortisone layering MCC mcc spheres Metoprolol Succinate Microcrystalline Cellulose Microparticles monodispersity multiparticulates multiple unit pellet system MUPS paediatrics pellets pH dependency Prednisolone process acceleration process parameter size size distribution solubility sphericity spouted bed Spray drying Sugar Spheres surface roughness taste masking uniformity Wurster

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