Pellets: Oral solid dosage forms
Pellets: Most convenient oral solid dosage form for every age
To clarify, multiparticulates – such as micro pellets, granules or mini tablets – serve the best oral dosage form for small children and elderly adults.
Rotor dry powder layering for pellet layering
Dry powder layering is a process for constructing active substance pellets. For instance, a starter core is coated with an ingredient in powder form. Nonetheless, a binding solution helps fixing the ingredient to the starter core. There is certainly a main advantage of this process compared to layering with liquid active substances: The processing time is significantly reduced which leads to a higher efficiency. With optimal process settings, hourly weight gains of up to 300 percent are possible.
On the other hand, rotor dry powder layering is the method of choice, if the API cannot be mixed up in liquids, but needs dry processing.
The result are dust-free, very round active substance pellets with a narrow particle size distribution. Therefore, rotor dry powder layering is an efficient solution for refining and functionalizing solids.
starter pellets ≥ 100 µm
processing of the API
as a powder
less than approx. 10% – 80%
smallest pellet size achievable
approx. 300 µm micropellets
high dosed or moisture sensitive API