Case Studies

Amorphous solid dispersions at various aspects part 2ingredient pharm

Amorphous solid dispersions at various aspects

We identified, that amorphous solid dispersions gain in importance as they increase the solubility and dissolution rate of poorly water-soluble drugs. There are severall attempts, in which each of them positive aspects and certain issues occur.…
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titelbild - Hydrodynamic behavior of MCC Spheres in a spouted bedingredientpharm
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Hydrodynamic behavior of MCC Spheres in a spouted bed

Abstract This case study is a short abstract on spouted bed characteristics, following closely findings in the publication by J. Vanamu and A. Sahoo [1]. Spouted bed systems are of highest importance for all powder processing industries,…
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Cellets list of publication
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Scientific literature on MCC pellets (CELLETS)

Selected Scientific literature Please, find scientific literature on CELLETS®. This list is constantly updated and does not claim to be complete. If you are author, scientist or R&D specialist, please submit your present publication to…
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muliparticulates-titleingredientpharm

Coating weight gain and API release in multiparticulates

Abstract Multiparticulates made of pellets are ideal dosage forms to be used in pediatrics. Having the suitability of paediatric consumers in mind, formulations of small-sized pellets offer a valuable base for increased compliance and improved…
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Metoprolol pellets

Metoprolol Tartrate: controlled release drug layered pellets for colon-specific drug delivery

Abstract on Metoprolol pellets Metoprolol Tartrate is a salt of Metoprolol, a selective β1-receptor blocker medication. The application is the treatment of high blood pressure, chest pain due to poor blood flow to the heart, and several conditions…
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Figure 3: SEM picture of cross section of a Taste masked pellets coated with 25 mg Eudragit EPO.
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Atomoxetine HCl Pellets in MUPS Formulations

Abstract This case study on Atomoxetine HCl pellets is a short abstract of the publication by Y.D. Priya et al. [1]. Atomoxetine is a medication used to treat attention deficit hyperactivity disorder (ADHD) [2]. The API is marketed under…
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Taste masked coated micropellets
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Tamoxifen citrate was spray layered micropellets for Cre recombination research

Abstract on Tamoxifen Tamoxifen is widely used in transgenic research in mice to induce Cre recombinase activity and achieve conditional gene knockouts [1]. However administrating tamoxifen to mice is challenging The commonly used dosing methods…
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Advantages of technological methods compared to a pure API usage.Ingredient Pharm
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Technologies for enhancing bioavailability of Simvastatin

Abstract This application note is based on content from Pohlen et al. [1]. Simvastatin (CAS number 79902-63-9) is a cholesterol-lowering agent with a low bioavailability of 5% [2,3]. This API is formulated as a lipid based drug delivery system…
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Close-up SEM images of Cellets® 500 particles coated with sodium benzoate at process conditions as printed in Table 2 (bold).

Multidimensional Correlation of Surface Smoothness and Process Conditions

Abstract Multidimensional Correlation of Surface Smoothness and Process Conditions is a necessary attempt to better understand, optimize and outperform process steps of drug formulations. Particle coating and layering in a fluidized bed process…
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Figure 4: Images of a Jelly without (left) and with incorporation of sustained release micropellets (right).

Gliclazide formulations for Sustained Release Delivery

Abstract Patients with dysphagia may have obstacles to swallow tablets or large multiparticulates. The former dosage form can even not be crushed in case that the tablet exhibits a modified release or taste-masking profile through outer layering.…
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Figure 2: SEM image of drug loaded and coated starter beads. Particles show a high level of homogeneity in size distribution.

Microparticle coating in Wurster Fluidized Bed – Scalable Production of Oral Sustained-Release Drugs

Abstract Modified drug release formulations for suspensions are a perfect solution for children and patients with swallowing difficulties. In many cases, these formulations are based on pellets serving as starter beads. In this report, an attempt…
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Coating uniformity of hot-melt coated particles Figure 2 (pure)

Coating uniformity of hot-melt coated particles

Abstract Coating uniformity is a critical parameter in coating processes in novel pharmaceutical formulations. Speaking about pellet technology, coating and layering are the main methods for implementing drug functionalities, such as modified…
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Fig. 3: Dissolution as a function of time. Black: ASD layered pellets (FB). Red: ASD pellets from direct pelletization (SB). Blue: physical mixture.

Amorphous solid dispersions layered pellets

Abstract Amorphous solid dispersions layered pellets solve a problem of poorly water soluble drugs. Speaking about oral drug formulations, drug carrier solutions based on starter cores are suitable for several drug classes and open new opportunities…
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Figure-3Ingredientpharm
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Impact of the particle size on powder behavior in a Wurster fluid-bed process

Abstract Cellets are inert starter cores made of microcrystalline cellulose (MCC). They play an important role in new formulations of solid dosage forms. As a carrier system for actives, the chemical inertness and surface smoothness are crucial…
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Pellets and micropellets can be further processed into a wide rangeglatt.com
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The path to the perfect sphere

The renaissance of micropellets is promoting innovative technologies In recent years, formulations based on pellets and micropellets have been the trend. New technologies make it possible to circumvent property rights for active ingredients…
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Cellets_350-1-3ingredientpharm
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Some light on sugar and microcrystalline cellulose pellets

Abstract Microcrystalline cellulose pellets (MCC) and sugar are well-known materials in pellet technology. Pellet technology describes the drug load onto starter pellets for controlled release formulations by Wurster process or others. Inert…
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CS_hydrocortisone_image_5

Case Study: Hydrocortisone for paediatrics

Abstract Hydrocortisone is found on the EMA unmet medical need priority list (2011) for the use in paediatric population for children suffering from all forms of adrenal insufficiency. Although there is a particular need in neonates and in…
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CS_sphericity_image_1
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Sphericity and size distribution of µm-sized microcrystalline pellets

Abstract Microcrystalline Cellulose (MCC) pellets represent a chemically inert class of active pharmaceutical ingredients (API) carriers. A narrow particle size distribution (PSD) maximizes control over content uniformity. In this case study,…
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CS_taste_image_1

Taste-masked cellulose based pellets for compaction

Abstract Several drug substances are known to be extremely bitter. In special for paediatric and geriatric applications, costumer compliance by means of taste acceptance is a highly sensitive topic. Taste masking is therefore an important issue…
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MUPS_image_4
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Better MUPS tablets: Aspects of MCC starter beads

Abstract Starter beads such as pellets made of microcrystalline cellulose (MCC) are frequently used in the formulation of oral drug delivery systems, e.g. multiparticulates [1] or multi-unit pellet system (MUPS) tablets [2]. Certain properties…
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Theophylline size distribution

Case Study: Layering of Theophylline

Abstract Theophylline is a powerful active used for the acute treatment of respiratory distress. Its bioavailability and uptake rates are high. Drug carrier systems are pellets made of sugar or microcrystalline cellulose (MCC). This case study…
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