Case Studies
Atomoxetine HCl Pellets in MUPS Formulations
Abstract
This case study on Atomoxetine HCl pellets is a short abstract of the publication by Y.D. Priya et al. [1].
Atomoxetine is a medication used to treat attention deficit hyperactivity disorder (ADHD) [2]. The API is marketed under…
Tamoxifen citrate was spray layered micropellets for Cre recombination research
Abstract on Tamoxifen
Tamoxifen is widely used in transgenic research in mice to induce Cre recombinase activity and achieve conditional gene knockouts [1]. However administrating tamoxifen to mice is challenging The commonly used dosing methods…
BSC Class I APIs in oral formulations
Technologies for enhancing bioavailability of Simvastatin
Abstract
This application note is based on content from Pohlen et al. [1]. Simvastatin (CAS number 79902-63-9) is a cholesterol-lowering agent with a low bioavailability of 5% [2,3]. This API is formulated as a lipid based drug delivery system…
Multidimensional Correlation of Surface Smoothness and Process Conditions
Abstract
Multidimensional Correlation of Surface Smoothness and Process Conditions is a necessary attempt to better understand, optimize and outperform process steps of drug formulations. Particle coating and layering in a fluidized bed process…
Gliclazide formulations for Sustained Release Delivery
Abstract
Patients with dysphagia may have obstacles to swallow tablets or large multiparticulates. The former dosage form can even not be crushed in case that the tablet exhibits a modified release or taste-masking profile through outer layering.…
Microparticle coating in Wurster Fluidized Bed – Scalable Production of Oral Sustained-Release Drugs
Abstract
Modified drug release formulations for suspensions are a perfect solution for children and patients with swallowing difficulties. In many cases, these formulations are based on pellets serving as starter beads. In this report, an attempt…
Faster drug release of enteric coated microparticles in bicarbonate buffers media
Coating uniformity of hot-melt coated particles
Abstract
Coating uniformity is a critical parameter in coating processes in novel pharmaceutical formulations. Speaking about pellet technology, coating and layering are the main methods for implementing drug functionalities, such as modified…
Amorphous solid dispersions layered pellets
Abstract
Amorphous solid dispersions layered pellets solve a problem of poorly water soluble drugs. Speaking about oral drug formulations, drug carrier solutions based on starter cores are suitable for several drug classes and open new opportunities…
Scientific literature on MCC pellets (CELLETS)
Selected Scientific literature
Please, find scientific literature on Cellets. This list is constantly updated and does not claim to be complete. If you are author, scientist or R&D specialist, please submit your present publication to us…
Impact of the particle size on powder behavior in a Wurster fluid-bed process
Abstract
Cellets are inert starter cores made of microcrystalline cellulose (MCC). They play an important role in new formulations of solid dosage forms. As a carrier system for actives, the chemical inertness and surface smoothness are crucial…
The path to the perfect sphere
The renaissance of micropellets is promoting innovative technologies
In recent years, formulations based on pellets and micropellets have been the trend. New technologies make it possible to circumvent property rights for active ingredients…
Some light on sugar and microcrystalline cellulose pellets
Abstract
Microcrystalline cellulose pellets (MCC) and sugar are well-known materials in pellet technology. Pellet technology describes the drug load onto starter pellets for controlled release formulations by Wurster process or others. Inert…
Case Study: Hydrocortisone for paediatrics
Abstract
Hydrocortisone is found on the EMA unmet medical need priority list (2011) for the use in paediatric population for children suffering from all forms of adrenal insufficiency. Although there is a particular need in neonates and in…
Sphericity and size distribution of µm-sized microcrystalline pellets
Abstract
Microcrystalline Cellulose (MCC) pellets represent a chemically inert class of active pharmaceutical ingredients (API) carriers. A narrow particle size distribution (PSD) maximizes control over content uniformity. In this case study,…
Taste-masked cellulose based pellets for compaction
Abstract
Several drug substances are known to be extremely bitter. In special for pediatric and geriatric applications, costumer compliance by means of taste acceptance is a highly sensitive topic. Taste masking is therefore an important issue…
Better MUPS tablets: Aspects of MCC starter beads
Abstract
Starter beads such as pellets made of microcrystalline cellulose (MCC) are frequently used in the formulation of oral drug delivery systems, e.g. multiparticulates [1] or multi-unit pellet system (MUPS) tablets [2]. Certain properties…
Case Study: Layering of Theophylline
Abstract
Theophylline is a powerful active used for the acute treatment of respiratory distress. Its bioavailability and uptake rates are high. Drug carrier systems are pellets made of sugar or microcrystalline cellulose (MCC). This case study…