Case Studies

fig-3_Plasticity of Microcrystalline Cellulose Spheres

The Increase in the Plasticity of Microcrystalline Cellulose Spheres’ When Loaded with a Plasticizer

Abstract Compaction pressure can induce an undesirable solid-state polymorphic transition in drugs, fragmentation, loss of coated pellet integrity, and the decreased viability and vitality of microorganisms. Thus, the excipients with increased…

Glatt

CELLETS®, Generell

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CELLETS®, CELLETS® 100, CELLETS® 1000, CELLETS® 200, CELLETS® 350, CELLETS® 500, CELLETS® 700

Scientific literature on MCC pellets (CELLETS)

Selected Scientific literature Please, find scientific literature on CELLETS®, MCC spheres. This list is constantly updated and does not claim to be complete. If you are author, scientist or R&D specialist, please submit your present publication…

CELLETS®, CELLETS® 700

The Effect of Design and Size of the Fluid-Bed Equipment on the Particle Size-Dependent Trend of Particle Coating Thickness and Drug Prolonged-Release Profile

Abstract The focus of the current work is to study and demonstrate the impact of the design, the scale, and settings of fluid-bed coating equipment on the differences in pellet coating thickness, which in case of prolonged-release pellets…

CELLETS®, CELLETS® 500, Generell

Continuous Manufacturing of Cocrystals Using 3D-Printed Microfluidic Chips Coupled with Spray Coating

Abstract on Continuous Manufacturing Using cocrystals has emerged as a promising strategy to improve the physicochemical properties of active pharmaceutical ingredients (APIs) by forming a new crystalline phase from two or more components.…

CELLETS®, CELLETS® 1000, CELLETS® 500, CELLETS® 700

Modelling the disintegration of pharmaceutical tablets: integrating a single particle swelling model with the discrete element method

Development of a New Bioequivalent Omeprazole Product

ingredientpharm

CELLETS®, CELLETS® 700

Development of a New Bioequivalent Omeprazole Product

The publication by G. Kumisbek, D. Vetchý, A. Kadyrbay describes gently the development and implementation of a new generic enteric form of CELLETS® 700 (MCC pellets, 700-1000 µm) loaded with omeprazole in capsules by Viva Pharm LLP, a pharmaceutical…

CELLETS®, CELLETS® 350, CELLETS® 700

Paediatric solid oral dosage forms for combination products: Improving in vitro swallowability of minitablets using binary mixtures with pellets

Abstract on paediatric solid oral dosage forms There is a growing interest in enhancing the acceptability of paediatric pharmaceutical formulations. Solid oral dosage forms (SODF), especially multiparticulates, are being considered as an…

CELLETS®, CELLETS® 200

Comparison of Mini-Tablets and Pellets as Multiparticulate Drug Delivery Systems for Controlled Drug Release

Abstract Mini-tablets made into hard capsules or administered using special dosing units, as well as pellets in hard capsules or compressed into tablets, offer the advantages of multiparticulate drug delivery systems and are suitable for controlled…

CELLETS® 700

Investigating the Influence of Fluid-Bed Equipment Design and Size on Particle Coating Thickness Trends and Drug Prolonged-Release Profiles Linked to Particle Size

The primary objective of this research is to investigate the design and size on particle coating thickness. Furthermore, illustrate how the design, size, and configurations of fluid-bed coating machinery influence variations in pellet coating…

Critical aspects of starter spheres in oral pellet formulations one should consider

ingredientpharm

CELLETS®, CELLETS® 100, CELLETS® 1000, CELLETS® 200, CELLETS® 350, CELLETS® 500, CELLETS® 700

Critical aspects of starter spheres in oral pellet formulations one should consider

Preparation and characterization of controlled-release doxazosin mesylate pellets

ingredientpharm

CELLETS® 700

Preparation and characterization of controlled-release doxazosin mesylate pellets using a simple drug layering-aquacoating technique

Abstract Pellets are one of multiparticulate pharmaceutical forms and can offer numerous technical and biopharmaceutical advantages compared with single dose unit formulations, e.g. tablets and capsules. This study aimed at formulation…

CELLETS® 700

Design and Optimization of a Nanoparticulate Pore Former as a Multifunctional Coating Excipient for pH Transition-Independent Controlled Release of Weakly Basic Drugs for Oral Drug Delivery

Abstract Bioavailability of weakly basic drugs may be disrupted by dramatic pH changes or unexpected pH alterations in the gastrointestinal tract. Conventional organic acids or enteric coating polymers cannot address this problem adequately…

CELLETS® 1000

Amorphous Solid Dispersions Layered onto Pellets – An Alternative to Spray Drying?

This article "Amorphous Solid Dispersions Layered onto Pellets - An Alternative to Spray Drying?" is an excerpt from the publication of Neuwirth et al., Pharmaceutics 2023, 15(3), 764; https://doi.org/10.3390/pharmaceutics15030764. Abstract Spray…

Benefits of multilayer high drug-loaded amorphous solid dispersions

CELLETS® 700

Benefits and challenges of multilayer high drug-loaded amorphous solid dispersions

Introduction on amorphous solid dispersions What is the benefit of multilayer amorphous solid dispersions? Recently, several studies had been performed on amorphous solid dispersions working spheres or starter beads. Starter beads, such as…

Amorphous solid dispersions at various aspects part 2

ingredient pharm

CELLETS®

Amorphous solid dispersions at various aspects

We identified, that amorphous solid dispersions gain in importance as they increase the solubility and dissolution rate of poorly water-soluble drugs. There are severall attempts, in which each of them positive aspects and certain issues occur.…

titelbild - Hydrodynamic behavior of MCC Spheres in a spouted bed

ingredientpharm

CELLETS® 1000, CELLETS® 700

Hydrodynamic behavior of MCC Spheres in a spouted bed

Abstract This case study is a short abstract on spouted bed characteristics, following closely findings in the publication by J. Vanamu and A. Sahoo [1]. Spouted bed systems are of highest importance for all powder processing industries,…

ingredientpharm

CELLETS® 200

Coating weight gain and API release in multiparticulates

Abstract Multiparticulates made of pellets are ideal dosage forms to be used in pediatrics. Having the suitability of paediatric consumers in mind, formulations of small-sized pellets offer a valuable base for increased compliance and improved…

CELLETS® 700

Metoprolol Tartrate: controlled release drug layered pellets for colon-specific drug delivery

Abstract on Metoprolol pellets Metoprolol Tartrate is a salt of Metoprolol, a selective β1-receptor blocker medication. The application is the treatment of high blood pressure, chest pain due to poor blood flow to the heart, and several conditions…

Figure 3: SEM picture of cross section of a Taste masked pellets coated with 25 mg Eudragit EPO.

CELLETS® 100, CELLETS® 200

Atomoxetine HCl Pellets in MUPS Formulations

Abstract This case study on Atomoxetine HCl pellets is a short abstract of the publication by Y.D. Priya et al. [1]. Atomoxetine is a medication used to treat attention deficit hyperactivity disorder (ADHD) [2]. The API is marketed under…

CELLETS® 100, Generell

Tamoxifen citrate was spray layered micropellets for Cre recombination research

Abstract on Tamoxifen Tamoxifen is widely used in transgenic research in mice to induce Cre recombinase activity and achieve conditional gene knockouts [1]. However administrating tamoxifen to mice is challenging The commonly used dosing methods…

Pellet sizes for potential MUPS and capsule formulations

ingredientpharm

CELLETS®, CELLETS® 100, CELLETS® 1000, CELLETS® 200, CELLETS® 350, CELLETS® 500

BSC Class I APIs in oral formulations

Advantages of technological methods compared to a pure API usage.

Ingredient Pharm

CELLETS®, CELLETS® 200

Technologies for enhancing bioavailability of Simvastatin

Abstract This application note is based on content from Pohlen et al. [1]. Simvastatin (CAS number 79902-63-9) is a cholesterol-lowering agent with a low bioavailability of 5% [2,3]. This API is formulated as a lipid based drug delivery system…

CELLETS® 500

Multidimensional Correlation of Surface Smoothness and Process Conditions

Abstract Multidimensional Correlation of Surface Smoothness and Process Conditions is a necessary attempt to better understand, optimize and outperform process steps of drug formulations. Particle coating and layering in a fluidized bed process…

Figure 4: Images of a Jelly without (left) and with incorporation of sustained release micropellets (right).

CELLETS® 100

Gliclazide formulations for Sustained Release Delivery

Abstract Patients with dysphagia may have obstacles to swallow tablets or large multiparticulates. The former dosage form can even not be crushed in case that the tablet exhibits a modified release or taste-masking profile through outer layering.…

Figure 2: SEM image of drug loaded and coated starter beads. Particles show a high level of homogeneity in size distribution.

CELLETS® 100

Microparticle coating in Wurster Fluidized Bed – Scalable Production of Oral Sustained-Release Drugs

Abstract Modified drug release formulations for suspensions are a perfect solution for children and patients with swallowing difficulties. In many cases, these formulations are based on pellets serving as starter beads. In this report, an attempt…

Figure 2: Dissolution versus time from enteric coated prednisolone formulations. The acidic stage is present by a 0.1 M HCl solution for 2 hours, subsequently is switched to a phosphate buffer at pH 6.8 with a duration of 2 more hours.

CELLETS® 100, CELLETS® 1000

Faster drug release of enteric coated microparticles in bicarbonate buffers media

CELLETS® 1000

Coating uniformity of hot-melt coated particles

Abstract Coating uniformity is a critical parameter in coating processes in novel pharmaceutical formulations. Speaking about pellet technology, coating and layering are the main methods for implementing drug functionalities, such as modified…

Fig. 3: Dissolution as a function of time. Black: ASD layered pellets (FB). Red: ASD pellets from direct pelletization (SB). Blue: physical mixture.

CELLETS® 500

Amorphous solid dispersions layered pellets

Abstract Amorphous solid dispersions layered pellets solve a problem of poorly water soluble drugs. Speaking about oral drug formulations, drug carrier solutions based on starter cores are suitable for several drug classes and open new opportunities…

Ingredientpharm

CELLETS® 100, CELLETS® 200, CELLETS® 350

Impact of the particle size on powder behavior in a Wurster fluid-bed process

Abstract Cellets are inert starter cores made of microcrystalline cellulose (MCC). They play an important role in new formulations of solid dosage forms. As a carrier system for actives, the chemical inertness and surface smoothness are crucial…

Pellets and micropellets can be further processed into a wide range

glatt.com

CELLETS®, CELLETS® 100, CELLETS® 200, CELLETS® 350, CELLETS® 500

The path to the perfect sphere

The renaissance of micropellets is promoting innovative technologies In recent years, formulations based on pellets and micropellets have been the trend. New technologies make it possible to circumvent property rights for active ingredients…

ingredientpharm

CELLETS®, CELLETS® 200, CELLETS® 350, CELLETS® 500

Some light on sugar and microcrystalline cellulose pellets

Abstract Microcrystalline cellulose pellets (MCC) and sugar are well-known materials in pellet technology. Pellet technology describes the drug load onto starter pellets for controlled release formulations by Wurster process or others. Inert…

CELLETS® 350

Case Study: Hydrocortisone for paediatrics

CELLETS®, CELLETS® 100, CELLETS® 200, CELLETS® 350, CELLETS® 500

Sphericity and size distribution of µm-sized microcrystalline pellets

Abstract Microcrystalline Cellulose (MCC) pellets represent a chemically inert class of active pharmaceutical ingredients (API) carriers. A narrow particle size distribution (PSD) maximizes control over content uniformity. In this case study,…

CELLETS® 200

Taste-masked cellulose based pellets for compaction

Abstract Several drug substances are known to be extremely bitter. In special for paediatric and geriatric applications, costumer compliance by means of taste acceptance is a highly sensitive topic. Taste masking is therefore an important issue…

CELLETS® 100, CELLETS® 200

Better MUPS tablets: Aspects of MCC starter beads

Abstract Starter beads such as pellets made of microcrystalline cellulose (MCC) are frequently used in the formulation of oral drug delivery systems, e.g. multiparticulates [1] or multi-unit pellet system (MUPS) tablets [2]. Certain properties…

CELLETS® 100

Case Study: Layering of Theophylline

Abstract Theophylline is a powerful active used for the acute treatment of respiratory distress. Its bioavailability and uptake rates are high. Drug carrier systems are pellets made of sugar or microcrystalline cellulose (MCC). This case study…

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