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Amorphous solid dispersions API ASD bitter API cellets CELLETS® coating coating weight gain dissolution drug load Dysphagia film thickness fluidized bed friability geriatrics hot-melt Hydrocortisone layering MCC mcc spheres Microcrystalline Cellulose Microparticles monodispersity multiparticulates multiple unit pellet system MUPS paediatrics pellets pH dependency process acceleration process parameter size size distribution solid oral dosage form solubility sphericity spouted bed Spray drying Sugar Spheres surface roughness tablets Tartrazine taste masking uniformity Wurster

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