Pellet Technologies

First of all: pellets are starter beads. They consist of microcrystalline cellulose, tartaric acid, sugar or other materials. The beads have not only a diameter between 100 and 1,400 µm but also show a comparably small size distribution. Subsequently, this allows defined drug layering of API (active pharmaceutical ingredient). Similarly, drug layering of excipients targets modified release times of your product. Above all, perfect results can be obtained thanks to perfect pellet properties, such as low friability, high degree of sphericity and smooth surfaces.

What is the principle of pellet technologies?

In this paragraph, we shed some light on the principle of pellet technologies. In short, the API is fixed to the outside of a pellet by using a binder or by spray technology. To clarify, API contents of 0.1 % up to 80 % are possible. The pellet is also often coated with excipients (single or multiple coating), which take over technical functions. These functions are for example mechanical protection, or adjustment of the drug delivery system. Along with the selection of excipients, different drug release profiles can be achieved, such as delayed, targeted or pulsed release. Different process technologies can be employed for layering and coating.

In other words: With pellet technologies you are able to create your best choice of oral dosage form for your application.

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