UV Imaging of MUPS Tablets Stability, Functionality, and Outcomes
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UV Imaging of MUPS Tablets: Stability, Functionality, and Outcomes

Introduction to UV Imaging of MUPS Tablets

UV imaging of MUPS tablets (multiple unit pellet system) is a growing field in pharmaceutical research. These tablets combine many coated pellets into one compressed unit. After ingestion, the tablet breaks apart and releases the active pharmaceutical ingredient (API). Researchers explored whether multispectral UV imaging could track the degradation of acetylsalicylic acid (ASA) into salicylic acid (SA). The goal was to confirm that this non-destructive method could monitor stability inside these complex formulations.

Scientific Approach to UV Imaging of MUPS Tablets

The study used CELLETS® 700 as neutral microcrystalline cellulose cores. Scientists layered ASA on these cores and coated them with Eudragit RL PO. They then compressed the pellets into MUPS tablets. The tablets were stored at different temperatures and humidity levels for several months.

At each time point, the tablets were examined with multispectral UV reflectance imaging. This technology captured detailed spectral fingerprints across the surface. To interpret the data, the team applied partial least squares regression (PLS). They predicted the concentration of SA as the main degradation product. High-performance liquid chromatography (HPLC) provided reference values for comparison, ensuring accuracy.

Results of UV Imaging of MUPS Tablets

The outcomes showed that UV imaging worked well for tracking degradation inside the tablets. The predictions matched closely with HPLC results, proving the method’s reliability. Moreover, the technique detected even small amounts of salicylic acid despite the tablet’s protective coating.

Importantly, UV imaging did more than quantify. It created spatial maps that revealed where degradation occurred on the tablet surface. These maps gave new insights into stability that destructive tests could not provide. As a result, the method proved fast, precise, and suitable for quality control and stability studies.

Role of CELLETS® 700 in the Research

CELLETS® 700 played a key role in the experiment. These spherical microcrystalline cellulose pellets range from 700 to 1,000 µm. Their smooth, uniform surface made it easy to apply ASA and coatings evenly. In addition, their chemical stability ensured that imaging signals came only from the coating and degradation layers.

Because CELLETS® 700 are robust, they maintained their structure during compression. This consistency improved the reliability of UV imaging results. Thus, the choice of these pellet cores supported both the technical and analytical goals of the study.

Conclusion

UV imaging of MUPS tablets offers a powerful tool for monitoring stability and degradation. By combining multispectral imaging with statistical modeling, researchers gained accurate and non-destructive insights into tablet quality. CELLETS® 700 provided the structural foundation that made the method effective. Consequently, this approach holds promise as a process-analytical technology for pharmaceutical development and quality assurance.

References

UV imaging of multiple unit pellet system (MUPS) tablets: A case study of acetylsalicylic acid stability
European Journal of Pharmaceutics and Biopharmaceutics, Volume 119, October 2017, Pages 447-453
Anna Novikova, Jens M. Carstensen, Thomas Rades, Claudia S. Leopold

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CELLETS® in Malodor Control Compositions

CELLETS® in Malodor Control Compositions: A Patent Overview

Introduction to Malodor Control Technology

CELLETS® in malodor control compositions mark a new step in odor management. Unpleasant smells from sulfur compounds, volatile organic compounds, aldehydes, and acids are often hard to control. Even more challenging are complex fishy odors that do not come from amines. Traditional solutions often fall short in both efficiency and usability.

The patent application US20250082809, filed by Kalykos LLC, introduces a new approach. It combines high-performance materials with practical handling benefits. As a result, the invention applies across personal care, healthcare, packaging, and industrial products.

The Patent’s Core Innovation

The patent centers on spherical activated carbon particles. These particles have high sphericity, which improves flow, reduces dust, and lowers abrasion. At the same time, they offer large surface areas and strong adsorption capacity. Because of these features, they capture difficult odors more effectively than irregular powders.

The compositions also include active agents such as acids, bases, or odor-neutralizing additives. Manufacturers can coat, spray, immerse, or blend these agents into the particles. This flexibility makes the system suitable for a wide range of products, from diapers and wound dressings to food packaging and air filters. Moreover, the spherical shape supports consistent coatings and safer handling during production.

The Role of CELLETS® in Malodor Control Compositions

A key highlight of this patent is the role of CELLETS®, also known as spherical cellulose particles. Unlike the activated carbon spheres, CELLETS® do not focus on adsorption. Instead, they work as carriers and support agents that improve the overall performance of the formulation.

CELLETS® come from microcrystalline cellulose and form into uniform spheres. Their size can range from 100 to 1400 micrometers. Because of their shape, they flow well, create little dust, and allow even coatings. These features make them valuable in manufacturing and product design.

In this system, CELLETS® can hold coatings of wax or phase change materials. They can also carry odor-control additives and release them in a controlled way (controlled release). Through this role, CELLETS® extend the active life of the carbon-based particles. They also add versatility, since different coatings or agents can adapt the product to specific needs.

When combined, activated carbon particles and CELLETS® create a dual system. The carbon provides strong odor adsorption. The cellulose spheres provide handling benefits, controlled release, and structural support. Together, they deliver a balanced and innovative solution.

Conclusion

The patent offers a major advance in odor control technology. It joins the adsorption strength of spherical carbon with the support and carrier functions of CELLETS®. This combination delivers both performance and usability. CELLETS® in malodor control compositions enhance reliability and open new possibilities for industries that demand effective and adaptable odor solutions.

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