Entries by Bastian Arlt

Scientific literature on MCC pellets (Cellets)

Selected Scientific literature Please, find scientific literature on Cellets. This list is constantly updated and does not claim to be complete. If you are author, scientist or R&D specialist, please submit your present publication to us for improving the visibility. List Research article Measurement of hydrogen peroxide vapor in powders with potassium titanium oxide oxalate […]

Impact of the particle size on powder behavior in a Wurster fluid-bed process

Abstract Cellets are inert starter cores made of microcrystalline cellulose (MCC). They play an important role in new formulations of solid dosage forms. As a carrier system for actives, the chemical inertness and surface smoothness are crucial parameters. Additionally, high level of robustness and sphericity simplify formulations and technical processes, such as fluidized bed technologies […]

The path to the perfect sphere

The renaissance of micropellets is promoting innovative technologies In recent years, formulations based on pellets and micropellets have been the trend. New technologies make it possible to circumvent property rights for active ingredients and are therefore very popular with pharmaceutical customers. But which technologies are the most important? Pellets are the jack-of-alltrades of solid dosage […]

Some light on sugar and microcrystalline cellulose pellets

Abstract Microcrystalline cellulose pellets (MCC) and sugar are well-known materials in pellet technology. Pellet technology describes the drug load onto starter pellets for controlled release formulations by Wurster process or others. Inert pellets are made of microcrystalline cellulose, while water soluble pellets are composed of sugar. Both material classes show desirable characteristics, such as a […]

Case Study: Hydrocortisone for paediatrics

Abstract Hydrocortisone is found on the EMA unmet medical need priority list (2011) for the use in paediatric population for children suffering from all forms of adrenal insufficiency. Although there is a particular need in neonates and in infants, i.e. children younger than two years, there is a main issue. No licensed hydrocortisone preparation for […]

Sphericity and size distribution of µm-sized microcrystalline pellets

Abstract Microcrystalline Cellulose (MCC) pellets represent a chemically inert class of active pharmaceutical ingredients (API) carriers. A narrow particle size distribution (PSD) maximizes control over content uniformity. In this case study, we will focus on measuring the particle size distribution and on sphericity. Pellets for oral drug forms MCC pellets are used as starter beads […]

Taste-masked cellulose based pellets for compaction

Abstract Several drug substances are known to be extremely bitter. In special for pediatric and geriatric applications, costumer compliance by means of taste acceptance is a highly sensitive topic. Taste masking is therefore an important issue in pharmaceutical industry of oral dosage forms not only to improve the compliance, but it is also used to […]

Better MUPS tablets: Aspects of MCC starter beads

Abstract Starter beads such as pellets made of microcrystalline cellulose (MCC) are frequently used in the formulation of oral drug delivery systems, e.g. multiparticulates [1] or multi-unit pellet system (MUPS) tablets [2]. Certain properties are requested to MCC pellets. We shed some light on sphericity size and friability in this note. Starter beads for MUPS […]

Case Study: Layering of Theophylline

Abstract Theophylline is a powerful active used for the acute treatment of respiratory distress. Its bioavailability and uptake rates are high. Drug carrier systems are pellets made of sugar or microcrystalline cellulose (MCC). This case study will point on the specific advantages of MCC pellets. Layering on starter pellets Basically, theophylline is an alkaloid that […]