Entries by Bastian Arlt

The development of an innovative method to improve the dissolution performance of rivaroxaban

This article [1] on the development of an innovative method to improve the dissolution performance of rivaroxaban was first published here. Abstract The dissolution performance of rivaroxaban has become a critical focus in pharmaceutical research, as this hydrophobic drug is practically insoluble in water, limiting its absorption and therapeutic effectiveness. Recent advancements in formulation strategies […]

18. August 2026 by
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Control Strategy for Wurster Coating: Precision and Innovation in Pharmaceutical Pellet Technology

Control Strategy for Wurster Coating and Its Importance in Modern Drug Formulation Control Strategy for Wurster Coating plays a central role in the production of high-quality pharmaceutical pellets for extended-release drug products. In multiparticulate formulations, coating efficiency and coating accuracy determine the final drug release profile. Therefore, manufacturers must control coating thickness with high precision. […]

18. August 2026 by

Formulation and Design of Multiunit Particulate Systems: A QbD Approach for Pantoprazole MUPS Tablets

The Role of Pellets in Advanced Oral Drug Delivery Formulation and design of multiunit particulate systems play a central role in modern oral drug delivery. Pellets used in Multiunit Particulate Systems (MUPS) distribute the active ingredient into many small units. As a result, they reduce the risk of dose dumping and minimize local irritation. In […]

18. August 2026 by
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Multilayered pharmaceutically active compound-releasing microparticles in a liquid dosage form

Introduction to Multilayered Pharmaceutically Active Compound Technology Multilayered pharmaceutically active compound-releasing microparticles in a liquid dosage form represent an innovative approach to oral drug delivery. This technology combines the benefits of coated pellets with the convenience of liquid administration. Effervescent tablets are solid dosage forms that release carbon dioxide when they dissolve in water. This […]

21. July 2026 by

Formulation and design of multiunit particulate systems

Introduction to the Formulation and Design of Multiunit Particulate Systems Formulation and design of multiunit particulate systems focus on oral dosage forms that contain many small, functional subunits instead of one single unit. These systems typically consist of pellets, granules, or coated spheres that are filled into capsules or compressed into tablets. As a result, […]

21. July 2026 by
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Influence of Water on the Structure of MCC

Influence of Water on the Structure of MCC Influence of Water on the Structure of MCC describes how moisture reshapes microcrystalline cellulose at both structural and dielectric levels [1]. Water interacts strongly with hydroxyl groups on cellulose chains. Therefore, it changes hydrogen bonding and mobility inside amorphous and crystalline regions. Moreover, the system develops distinct […]

21. July 2026 by
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MCC pellets under rheological investigation

MCC pellets under rheological investigation MCC pellets under rheological investigation are ideal model spheres for studying powder behavior. In this study, we revisit the work of V. Mohylyuk and R. Dattani to analyze the effect of pellet size on powder properties. Understanding how pellet size influences flow and handling is essential for optimizing powder performance. […]

21. July 2026 by
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Scientific Literature on MCC Pellets: Insights into CELLETS®

Research Advances in MCC Pellet Technology and Applications Scientific literature on MCC pellets highlights the growing importance of CELLETS® in pharmaceutical and scientific research. These microcrystalline cellulose spheres play a key role in developing reliable multiparticulate drug delivery systems. Researchers have investigated improved rivaroxaban dissolution, efficient film coating kinetics, and their use in orally disintegrating […]

15. June 2026 by
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Delayed release oral pharmaceutical compositions: scientific background, patent insights, and future potential

Introduction to delayed release oral pharmaceutical compositions Delayed release oral pharmaceutical compositions enable drug delivery at a defined time after oral administration. Unlike immediate release dosage forms, these systems control when the active pharmaceutical ingredient becomes available for absorption. As a result, they protect acid-sensitive drugs and allow targeted delivery to specific gastrointestinal regions. Moreover, […]

2. April 2026 by