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But we are proud to say that Bastian Arlt contributed 96 entries already.
Methylphenidate Modified Release Formulations and Their Clinical Importance Methylphenidate modified release formulations play a central role in modern ADHD treatment. These dosage forms control the rate and timing of drug release after administration. As a result, they maintain therapeutic drug levels over an extended period and reduce the need for multiple daily doses. Methylphenidate is […]
Abstract Multiparticulate formulations based on pellets, granules or beads, could be advantageous for paediatrics, geriatrics and patients with swallowing difficulties. However, these formulations may require suitable administration media to facilitate administration. The aim of this work was to investigate the effect of administration media properties on palatability and ease of swallowing of multiparticulates. A range […]
This article [1] on the development of an innovative method to improve the dissolution performance of rivaroxaban was first published here. Abstract The dissolution performance of rivaroxaban has become a critical focus in pharmaceutical research, as this hydrophobic drug is practically insoluble in water, limiting its absorption and therapeutic effectiveness. Recent advancements in formulation strategies […]
Control Strategy for Wurster Coating and Its Importance in Modern Drug Formulation Control Strategy for Wurster Coating plays a central role in the production of high-quality pharmaceutical pellets for extended-release drug products. In multiparticulate formulations, coating efficiency and coating accuracy determine the final drug release profile. Therefore, manufacturers must control coating thickness with high precision. […]
The Role of Pellets in Advanced Oral Drug Delivery Formulation and design of multiunit particulate systems play a central role in modern oral drug delivery. Pellets used in Multiunit Particulate Systems (MUPS) distribute the active ingredient into many small units. As a result, they reduce the risk of dose dumping and minimize local irritation. In […]
Introduction to Multilayered Pharmaceutically Active Compound Technology Multilayered pharmaceutically active compound-releasing microparticles in a liquid dosage form represent an innovative approach to oral drug delivery. This technology combines the benefits of coated pellets with the convenience of liquid administration. Effervescent tablets are solid dosage forms that release carbon dioxide when they dissolve in water. This […]
Introduction to the Formulation and Design of Multiunit Particulate Systems Formulation and design of multiunit particulate systems focus on oral dosage forms that contain many small, functional subunits instead of one single unit. These systems typically consist of pellets, granules, or coated spheres that are filled into capsules or compressed into tablets. As a result, […]
Influence of Water on the Structure of MCC Influence of Water on the Structure of MCC describes how moisture reshapes microcrystalline cellulose at both structural and dielectric levels [1]. Water interacts strongly with hydroxyl groups on cellulose chains. Therefore, it changes hydrogen bonding and mobility inside amorphous and crystalline regions. Moreover, the system develops distinct […]
MCC pellets under rheological investigation MCC pellets under rheological investigation are ideal model spheres for studying powder behavior. In this study, we revisit the work of V. Mohylyuk and R. Dattani to analyze the effect of pellet size on powder properties. Understanding how pellet size influences flow and handling is essential for optimizing powder performance. […]