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But we are proud to say that Bastian Arlt contributed 94 entries already.
Multiple-Unit Pellet System with Diclofenac Sodium represents a modern and flexible approach to oral drug delivery. This multiparticulate system divides the drug dose into many small pellets, each functioning as an individual unit. Because of this design, the formulation ensures more uniform gastrointestinal distribution and minimizes dose dumping. It also improves patient compliance and allows […]
Multiparticulate oral dosage form of tapentadol introduces a modern way to control drug release and improve pain management. The invention, described in patent US20250295596A1, replaces traditional monolithic extended-release tablets with numerous coated particles. This structure allows a smoother and more consistent release of tapentadol in the body. As a result, patients experience steadier pain relief, […]
Introduction to UV Imaging of MUPS Tablets UV imaging of MUPS tablets (multiple unit pellet system) is a growing field in pharmaceutical research. These tablets combine many coated pellets into one compressed unit. After ingestion, the tablet breaks apart and releases the active pharmaceutical ingredient (API). Researchers explored whether multispectral UV imaging could track the […]
Introduction to Malodor Control Technology CELLETS® in malodor control compositions mark a new step in odor management. Unpleasant smells from sulfur compounds, volatile organic compounds, aldehydes, and acids are often hard to control. Even more challenging are complex fishy odors that do not come from amines. Traditional solutions often fall short in both efficiency and […]
Hot-melt coating materials improve efficiency and product quality in pharmaceutical and industrial manufacturing. They melt when heated and solidify quickly, forming strong, uniform coatings on various surfaces. As a result, manufacturers reduce production time, lower costs, and avoid using solvents. Furthermore, understanding wetting behavior and delamination is critical to optimize coating performance. For example, CELLETS® […]
Introduction The development of a hydroxynorketamine modified-release dosage form marks an important advance in neuropsychiatric therapy. Hydroxynorketamine (HNK), a ketamine metabolite, shows rapid antidepressant activity through mechanisms different from ketamine itself. It works mainly by modulating α7-nicotinic acetylcholine receptors and activating mTOR pathways. This targeted action makes HNK a strong candidate as an active pharmaceutical […]
Introduction Gamma‑hydroxybutyrate (GHB) is an endogenous neurotransmitter also used pharmaceutically—usually as sodium oxybate—for treating narcolepsy and related disorders. It exerts its therapeutic effects by modulating GABA_B receptors and promoting slow-wave sleep, alleviating cataplexy, and reducing excessive daytime sleepiness. Despite its efficacy, current twice-nightly dosing regimens present challenges: dose‑dumping in the presence of alcohol, variable pharmacokinetics […]
Introduction Fixed-bed column adsorption is an essential process in modern water treatment systems, widely implemented due to its continuous operation, ease of design, and applicability in large-scale systems. In this method, a contaminant-laden liquid passes through a column packed with adsorbent material, facilitating efficient contaminant removal before discharge or reuse. While effective for many pollutants, […]
Abstract CELLETS, a new type of adsorbent, have emerged as a promising solution in water treatment. They are particularly effective in fixed-bed column systems for removing persistent organic pollutants, such as synthetic dyes. This summary reflects research published by Suteu et al. [1]. Fixed-bed adsorption is a well-established filtration method. It allows continuous treatment of […]
Introduction Fixed-bed column techniques are widely applied in water and wastewater treatment to achieve continuous adsorption of pollutants. In these systems, aqueous effluent flows through a packed bed of adsorbent material, offering operational simplicity, easy scale-up, and consistent performance—critical features in industrial and pharmaceutical settings. However, removing dyes from pharmaceutical effluents presents unique challenges: dyes […]