About Bastian Arlt
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Entries by Bastian Arlt
Sphericity and size distribution of µm-sized microcrystalline pellets
Abstract Microcrystalline Cellulose (MCC) pellets represent a chemically inert class of active pharmaceutical ingredients (API) carriers. A narrow particle size distribution (PSD) maximizes control over content uniformity. In this case study, we will focus on measuring the particle size distribution and on sphericity. Pellets for oral drug forms MCC pellets are used as starter beads […]
Taste-masked cellulose based pellets for compaction
Abstract Several drug substances are known to be extremely bitter. In special for paediatric and geriatric applications, costumer compliance by means of taste acceptance is a highly sensitive topic. Taste masking is therefore an important issue in pharmaceutical industry of oral dosage forms not only to improve the compliance, but it is also used to […]
Better MUPS tablets: Aspects of MCC starter beads
Abstract Starter beads such as pellets made of microcrystalline cellulose (MCC) are frequently used in the formulation of oral drug delivery systems, e.g. multiparticulates [1] or multi-unit pellet system (MUPS) tablets [2]. Certain properties are requested to MCC pellets. We shed some light on sphericity size and friability in this note. Starter beads for MUPS […]
Case Study: Layering of Theophylline
Abstract Theophylline is a powerful active used for the acute treatment of respiratory distress. Its bioavailability and uptake rates are high. Drug carrier systems are pellets made of sugar or microcrystalline cellulose (MCC). This case study will point on the specific advantages of MCC pellets. Layering on starter pellets Basically, theophylline is an alkaloid that […]