Yes, the flow of MCC pellets (Cellets) through a Wurster fluid-bed coater shows better performance as the Cellets’ particle size increases. The flow behavior is outperforming standard MCC powder. This was investigated by Mohylyuk et al. (2019), doi: 10.1016/j.jddst.2019.101320. Find more information: Is there an impact of the particle size on powder behavior in a Wurster fluid-bed process?
Impact of the particle size on powder behavior in a Wurster fluid-bed process: Compressibility at 10 kPa normal stress on Cellets with varying particle size (D50) and Avicel® PH-102.