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But we are proud to say that Bastian Arlt contributed 90 entries already.
The following patent on “Extended-release compositions comprising atomoxetine” employs CELLETS® as starter spheres made of Microcrystalline Cellulose. Please, read below a summary. United States Patent Application 20240299307 focuses on an extended-release formulation of atomoxetine, commonly used for treating ADHD. The patent describes a unique pellet-based drug delivery system designed to control the release of atomoxetine […]
This article “Influence of Polymer Film Thickness on Drug Release from Fluidized Bed Coated Pellets and Intended Process and Product Control” was published on Pharmaceutics 2024, 16(10), 1307; https://doi.org/10.3390/pharmaceutics16101307, under free licence on October 08, 2024 by Marcel Langner, Florian Priese, and Bertram Wolf. We performed modifications of the text for better readability. Abstract Background/Objectives: Coated drug pellets […]
Abstract Compaction pressure can induce an undesirable solid-state polymorphic transition in drugs, fragmentation, loss of coated pellet integrity, and the decreased viability and vitality of microorganisms. Thus, the excipients with increased plasticity can be considered as an option to decrease the undesirable effects of compaction pressure. This study aims to increase the plasticity (to reduce […]
Abstract The focus of the current work is to study and demonstrate the impact of the design, the scale, and settings of fluid-bed coating equipment on the differences in pellet coating thickness, which in case of prolonged-release pellets dictates the drug release. In the first set of coating experiments, the pellet cores were coated with […]
Abstract on Continuous Manufacturing Using cocrystals has emerged as a promising strategy to improve the physicochemical properties of active pharmaceutical ingredients (APIs) by forming a new crystalline phase from two or more components. Particle size and morphology control are key quality attributes for cocrystal medicinal products. The needle-shaped morphology is often considered high-risk and complex […]
The publication by G. Kumisbek, D. Vetchý, A. Kadyrbay describes gently the development and implementation of a new generic enteric form of CELLETS® 700 (MCC pellets, 700-1000 µm) loaded with omeprazole in capsules by Viva Pharm LLP, a pharmaceutical company based in Kazakhstan. The company’s solid-dosage-form production facility was utilized for this purpose. Detailed technological […]
Abstract on paediatric solid oral dosage forms There is a growing interest in enhancing the acceptability of paediatric pharmaceutical formulations. Solid oral dosage forms (SODF), especially multiparticulates, are being considered as an alternative to liquid formulations, but they may compromise palatability when large volumes are required for dosing. We hypothesised that a binary mixture of […]