Entries by Bastian Arlt

, ,

Different pelletization techniques: Introduction and Summary of the Thesis by Azza A. K. Mahmoud

Introduction to Different Pelletization Techniques and Their Functionality in Drug Formulations Different pelletization techniques form a core part of pharmaceutical manufacturing for solid dosage forms that deliver active pharmaceutical ingredients (APIs) with enhanced performance. Pelletization, a process that generates small, uniform spherical particles, improves flow properties, enables controlled or delayed release, and reduces local irritation […]

11. December 2025 by
, , , , , ,

Patent on enzyme-cleavable methadone prodrugs and methods of use thereof

Enzyme‑cleavable methadone prodrugs: Functionality, Opportunities, and Summary of US20250361205A1 Introduction to Enzyme‑cleavable methadone prodrugs Enzyme‑cleavable methadone prodrugs represent a novel class of pharmacological agents designed to provide controlled release of methadone only after specific enzymatic activation. These prodrugs attach an enzyme‑cleavable promoiety to the methadone molecule, rendering it inactive until a target enzyme cleaves the […]

11. December 2025 by

Cellulose-Derived Spherical Activated Carbon

Cellulose-derived spherical activated carbon is a sustainable carbon material made from renewable cellulose sources. It forms uniform spheres with high surface area and excellent porosity after activation. Because of its spherical shape, this carbon flows smoothly, packs efficiently, and resists dust formation. These traits make it ideal for pharmaceutical and biomedical uses. In drug formulation, […]

10. November 2025 by

Characterization of Layered Pellets and the Role of Amorphized Amlodipine Besylate / Hydrochlorothiazide

Characterization of layered pellets forms the basis of advanced pharmaceutical pellet design. These pellets consist of inert cores coated with active drug layers. Their detailed analysis ensures uniformity, strength, and consistent drug release. Layered systems offer precise dosing, extended or modified release, and taste masking. When the solid-state properties of the drug are modified through […]

13. October 2025 by
, ,

Cellulose-derived spherical activated carbon – sustainable nanoarchitectonics for efficient uremic toxin removal in pharmaceutical applications

Cellulose-Derived Spherical Activated Carbon Cellulose-derived spherical activated carbon offers a sustainable and efficient solution for adsorbing harmful compounds such as uremic toxins [1]. This carbon material is made from renewable cellulose, which is transformed into spherical particles and then activated to increase surface area and porosity. The spherical shape improves flow properties and reduces dust, […]

13. October 2025 by
,

Multiple-Unit Pellet System with Diclofenac Sodium

Multiple-Unit Pellet System with Diclofenac Sodium represents a modern and flexible approach to oral drug delivery. This multiparticulate system divides the drug dose into many small pellets, each functioning as an individual unit. Because of this design, the formulation ensures more uniform gastrointestinal distribution and minimizes dose dumping. It also improves patient compliance and allows […]

9. October 2025 by
, , , , , ,

Scientific Literature on MCC Pellets: Insights into CELLETS®

Research Advances in MCC Pellet Technology and Applications Scientific literature on MCC pellets highlights the growing importance of CELLETS® in pharmaceutical and scientific research. These microcrystalline cellulose spheres play a key role in developing reliable multiparticulate drug delivery systems. Researchers have investigated improved rivaroxaban dissolution, efficient film coating kinetics, and their use in orally disintegrating […]

7. October 2025 by
,

Multiparticulate Oral Dosage Form of Tapentadol

Multiparticulate oral dosage form of tapentadol introduces a modern way to control drug release and improve pain management. The invention, described in patent US20250295596A1, replaces traditional monolithic extended-release tablets with numerous coated particles. This structure allows a smoother and more consistent release of tapentadol in the body. As a result, patients experience steadier pain relief, […]

6. October 2025 by
,

UV Imaging of MUPS Tablets: Stability, Functionality, and Outcomes

Introduction to UV Imaging of MUPS Tablets UV imaging of MUPS tablets (multiple unit pellet system) is a growing field in pharmaceutical research. These tablets combine many coated pellets into one compressed unit. After ingestion, the tablet breaks apart and releases the active pharmaceutical ingredient (API). Researchers explored whether multispectral UV imaging could track the […]

30. September 2025 by

CELLETS® in Malodor Control Compositions: A Patent Overview

Introduction to Malodor Control Technology CELLETS® in malodor control compositions mark a new step in odor management. Unpleasant smells from sulfur compounds, volatile organic compounds, aldehydes, and acids are often hard to control. Even more challenging are complex fishy odors that do not come from amines. Traditional solutions often fall short in both efficiency and […]

17. September 2025 by